Natural gums are economic, easily available and found useful as tablet binder. Significant work was not reported on azadirachta indica gum to use in pharmaceuticals. Objective of the present work was to evaluate and characterized the azadirachta indica gum as a binder in tablet formulation. Tablets were prepared by using azadirachta indica gum as a binder and diclofenac sodium as a model drug. The concentration of the binder was varied from 2 to 12 % w/v in tablet formulations and was compared with the starch (10% w/v) as a standard binder. The evaluation granules prepared showed angle of repose of ranges from 29.21 to 34.27, friability 2.23 to 3.55 %. The hardness of tablet ranges from 4.2 to 4.6 kg/cm2 , disintegration time 7min to 18min., and maximum drug release 96.79 to 98.13 %. Useful concentration of azadirachta indica gum was found to be 8% with compare to starch (10%).
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